Serotonin – the Humanizing Neurochemical

Serotonin – the Humanizing Neurochemical

Serotonin and Mood

Serotonin , or 5 Hydroxytryptamine, is one of three major mood- defining chemicals in the brain. It is manufactured inside certain brain cells , from a protein ingredient called tryptophan. Many ask me if Serotonin is the “happiness” chemical . Not quite , but , like money , it helps.

It is the “ chemical of satisfaction”. Of peace . Of mediation and moderation .It’s associated with increased patience, tolerance toward ones fellow man , as well as feeling less affected emotionally by usual triggers- all those small daily occurrences that annoy or irk or upset us. And it promotes healthy sleep patterns.

I think that the remarkable thing about serotonin is that it seems to be the chemical that defines us as human , and not animal . What makes us uniquely human, different from other mammals? We all have animalistic basic drives, but what causes behaviour to be moderated ?

Free Choice

Humans have the implicit ability to choose their behaviors and actions. Instead of merely reacting to environmental stimuli , we have the ability to consider … and thus Respond.

If a lion is hungry , he must eat. And if there’s no food , he will eat you!

But you can decide that you’re skipping a meal for diet purposes, or because you are fasting for religious reasons .

An animal is incapable of this.

Reaction versus Response

As serotonin networks slow down , you would find yourself less able to temper your inner emotional responses. This leads to a problem controlling consequent behavioural reactions. A common example of this is a road rage episode. When serotonin networks are functioning at the correct speed , you should be able to do the following: look at the person who offended you, count to ten , breathe, and calmly decide whether to strike that person , or walk away , or hum a melody . I’m not judging these responses, but merely making the point that there is an ability to choose ones behavioural output – to respond instead of react. A dysfunctional serotonin system seems to render us more ‘animalistic’ Serotonin helps our ‘Human-ness’

A Glass of Milk?

How can we raise the frequency of our serotonin circuits , thereby refining our behaviour ? The answer is that this can be achieved in a variety of different ways – from listening to certain types of music ( try the featured Bach piece), practising mindfulness, taking serotonin boosting medications, and eating specific foodstuffs.

Have you ever heard – perhaps from a granny – that if you are stressed or can’t sleep, you should drink a glass of warm milk? Now, milk contains tryptophan, the essential building block of serotonin. I am still intrigued that a Ugandan patient remembers being given this remedy by his grandmother. and my gran from Paarl imparted the very same pearl. Clearly the drive to fire up ones serotonergic circuitry, to be calmer, sleep better and behave responsibly, in human fashion, is an age-old wisdom.

Bach Will Speed up Your Serotonin Everytime

Immune Dysfunction Kills in Covid but can it cause Depression?

Immune Dysfunction Kills in Covid but can it cause Depression?

 

We are learning more and more about Covid -19  – specifically about what kills.

The term “ Cytokine Storm “ is used to describe a massive build up of the body’s own immune system, with an outpouring of “ fighter – molecules”. These ‘soldiers’ are meant  to decimate the “intruder” – coronavirus.  In people who become alarmingly ill  it seems that this intense immune response actually  attacks the hosts own tissues and causes the brunt of the damage . 

A cell which divides in a manner that’s out of control becomes a tumor…………….. An out of control immune system kills the host – it’s like soldiers going to war against their own country . 

In Susannah Calahan’s book, entitled “Brain on fire – My month of Madness” , the author  – a New York journalist, describes how  she experienced symptoms of psychosis , and seizures… but that she was told that doctors could find nothing wrong . The tests she underwent were negative. Until a smart doctor found the cause  – Autoimmune Encephalitis  (anti NMDA receptor encephalitis). Dr Souhel Najjar is a neurologist  who identified the mechanism of interaction between the immune system and the central nervous system. This rare brain disease manifests with a strange combination of neurological and psychiatric symptoms  – due to an immune system that’s making warheads and targeting a part of the brain. The story of the journalist and the neurologist was made into a drama movie.

Recent research has focused on the possible role of inflammation as a cause of brain disorders, including depression. A person with diagnosed depression complains of low energy and cannot concentrate. They commonly stay in bed, and lose interest in the outside world. They therefore appear ‘sick’.

 There is certainly mounting evidence in the literature of a biological association for at least a certain spectrum of people diagnosed with depression as in fact tests for  inflammatory markers are raised in some depressed populations. But what causes the inflammation that becomes overdone, and thus self-defeating?

Stress

One idea is that as we live with greater amounts of stress, our body mounts an immune reaction to deal with stress itself. This response leads to an inflammatory build up in the brain – which can then manifest clinically with signs of depression.

Other conditions understood to be caused at least in part, by an out-of – control immune response , with raised neuroinflammatory markers are brain diseases such as Alzheimer’s and Parkinson’s, as well as certain brain tumours . Auto-immune diseases such as Lupus and Rheumatoid arthritis and some types of thyroid disease also fall into this category . 

While medical management of inflammation may involve use of immune suppresssants including corticosteroids and dexamethasone , and various antidepressant medications are available to treat serious depression, the one main factor we can try to address is the level of stress we perceive in our daily lives. We cannot avoid or escape stress, but we can minimise the impact it has on our bodies and on our Minds.

Future posts will detail tools for Stress reduction , but in brief , we should limit exposure to disturbing and anxiety- provoking media, maintain healthy eating and sleeping patterns, exercise, foster core relationships , and make time to have fun and relax .

Or we can do as Michael Singer, author of The Untethered Soul, suggests…..” It is not life’s events that are causing problems or stress. It is your resistance to life’s events that is causing this experience. Since the problem is caused by using your will to resist the reality of life passing through you, the solution is obvious – stop resisting.”

 

An Instant Mood Boost

An Instant Mood Boost

Harvard scientist Dr Bettina B Hoeppner, has described the use of positive psychology exercises in her research papers.

A study, published in the Journal of Substance Abuse Treatment, demonstrated the mood-boosting effect of certain exercises, in subjects who were “giving up” smoking and other drugs. In this study, subjects showed a definite increase in “in the moment happiness” compared to other techniques.

Martin Seligman,  author of the groundbreaking book, Flourish, says that we humans are “wired” to analyse and overthink bad events, therefore, we need to practice thinking positively – BUT THAT IT WORKS!! Focusing on good stuff ‘breaks up depression and brings happiness’

The exercises are Mindfulness Techniques that are free and easy to do.

Ill share these over my next couple of blogs and in addition, suggest we all make an effort to try these out – we can expect to feel an instant mood boost, and more lighthearted, positive and optimistic within a week

                                        Todays exercise is called THREE GOOD THINGS

 

Think back over your day. What are three good things that you experienced in the past 24 hours?

  • For best effect:
  •  – Write it down
  •  – Reflect on the event and immerse yourself in the situation for a few moments
  •  – Do this every night for a week